Indiana Rheumatology & Infusion Center, Dr. Fabiola Gamarra-Hilburn, New Albany, IN, Informational blog about Pegloticase

How to Get Rid of Gout Tophi: Is Pegloticase the Answer?

Gout is a painful and debilitating form of arthritis caused by the accumulation of uric acid crystals in the joints. In advanced cases, these crystals form tophi—hard, swollen lumps that can severely impact mobility and joint function. Traditional gout treatments often fall short in severe cases, but Pegloticase offers a breakthrough solution for chronic tophaceous gout.

Why is Pegloticase the Best Treatment for Severe Gout with Tophi?

Unlike conventional medications that either block uric acid production or promote its elimination, Pegloticase actively breaks down excess uric acid, leading to rapid tophi reduction. It’s an enzyme-based infusion therapy that converts uric acid into allantoin, a substance that dissolves easily in the urine, preventing further crystal formation.

How Effective is Pegloticase for Tophi Removal?

Research and clinical trials have demonstrated the power of Pegloticase in reducing tophi:

  • Up to 40% of patients experience complete tophus resolution within six months of treatment.
  • Significant pain and swelling reduction within the first few infusions.
  • Improved mobility and quality of life, making daily activities easier.

For those considering surgical removal of tophi, using Pegloticase beforehand can shrink or even eliminate tophi, making surgery less invasive or unnecessary.

Should You Use Pegloticase Before Surgery for Gout Tophi?

Surgical removal of tophi carries risks, including infection, nerve damage, and long recovery periods. By initiating Pegloticase therapy first, patients may:

  • Reduce the size of tophi, making surgery simpler and safer.
  • Improve joint function before undergoing an operation.
  • Potentially avoid surgery altogether if tophi dissolve completely.

Real Patient Success with Pegloticase

John, a 62-year-old living with chronic gout, was considering surgery after years of failed treatments. His rheumatologist recommended Pegloticase, and after six months of therapy, his tophi shrank by 80%, allowing him to walk pain-free without surgery.

Frequently Asked Questions (FAQs)

1. How long does it take for Pegloticase to work on tophi?
Most patients see noticeable improvement within a few months, with full tophus resolution in some cases by six to twelve months.

2. What are the risks of surgery for gout tophi?
Surgical risks include infection, nerve damage, and long recovery times. Pegloticase can help shrink tophi before surgery, making it a safer procedure—or eliminating the need altogether.

3. Is Pegloticase right for me?
If you have severe, uncontrolled gout with tophi, and standard medications haven’t worked, Pegloticase may be an excellent option. A consultation with a rheumatologist is essential to determine eligibility.

Take Control of Your Gout Today

At Indiana Rheumatology & Infusion Center, we specialize in advanced infusion therapies, including Pegloticase for severe gout. Our team of experienced rheumatology experts is dedicated to helping you reduce tophi, relieve pain, and improve mobility—all without unnecessary surgery.

Don’t wait until tophi limit your movement and daily life. Take action now!

  • Schedule a consultation today and get a personalized treatment plan.
  • Call us now to learn more about our infusion therapy options.
  • Visit our infusion center in Indiana for expert gout care and cutting-edge treatments.

Contact Indiana Rheumatology & Infusion Center Today!

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